Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Pomalidomide (CC-4047) 19171-19-8 200mg
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Pomalidomide (CC-4047) an immunomodulatory derivative structurally related to Thalidomide exhibits anti-tumor and anti-angiogenic properties Chemically the molecule is distinguished by additional amino substituent at the fourth position of the phthalimide ring and two extra oxy groups Its mechanism of action includes modulation of specific cytokines within the tumor microenvironment (TNF- IL-6 IL-8 VEGF) suppression of tumor cell proliferation and modification of host immune cell activity Pomalidomide is widely studied in biomedical research particularly in therapeutic exploration for hematologic malignancies such as multiple myeloma including relapsed or refractory disease states
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eMolecules 288154-18-7 | tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Combi-Blocks | MFCD04114477 | 243.307 | C11H21N3O3 | 98.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 25g | 439372829
tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Combi-Blocks | 288154-18-7 | MFCD04114477 | 243.307 | C11H21N3O3 | 98.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 25g | 439372829
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TARGETMOL CHEMICALS INC ON-01910 25MG
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Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. purity: 99%
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Medchemexpress LLC Amino-PEG8-amine | 82209-36-7 | 98.0% | 5 G
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Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker that is used in the synthesis of PROTACs. PROTACs are compounds that contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. These PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase.
- The other ligand is for the target protein.
- They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Apexbio Technology LLC Tubastatin A HCl 1310693-92-5 200mg
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Tubastatin A HCl (CAS 1310693-92-5) is a selective inhibitor of histone deacetylase 6 (HDAC6) exhibiting an IC50 of approximately 15 nM HDAC6 is involved in diverse cellular processes including transcriptional regulation cell cycle progression and neuronal development dysregulated HDAC6 activity is implicated in conditions such as Alzheimer s disease and cancer In primary cortical neuron models Tubastatin A HCl at concentrations of 5 10 M confers protection against neuronal toxicity caused by homocysteic acid In HaCaT cells its HDAC6-specific inhibition prevents arsenite-induced association of Nrf2 mRNA with ribosomes and subsequent protein translation Tubastatin A HCl also enhances cell elasticity by modulating HDAC6-mediated cytoskeletal dynamics
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Medchemexpress LLC MCC950 | 210826-40-7 | 99.8% | 200 MG
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MCC950 is a potent and selective NLRP3 inhibitor, with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs. It blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. This product is for research use only.
- Potent and selective NLRP3 inhibitor
- Blocks canonical and non-canonical NLRP3 activation
- Specifically inhibits NLRP3, not AIM2, NLRC4, or NLRP1
- Reduces interleukin-1β (IL-1β) production
- Attenuates the severity of experimental autoimmune encephalomyelitis (EAE)
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eMolecules EMOLECULES INC
5000841185 AZIDO-PEG4-AMINE 1G
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Medchemexpress LLC Linifanib | 796967-16-3 | 99.4% | C21H18FN5O | 200 MG
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Linifanib (ABT-869) is a potent, orally active, multi-target inhibitor of the VEGFR and PDGFR family. It demonstrates prominent antitumor activity and has significantly less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib also acts as a specific miR-10b inhibitor, blocking miR-10b biogenesis.
- Potent and orally active multi-target inhibitor of VEGFR and PDGFR family
- Exhibits prominent antitumor activity
- Significantly less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases
- Acts as a specific miR-10b inhibitor, blocking miR-10b biogenesis
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Medchemexpress LLC Orbifloxacin | 113617-63-3 | 99.8% | 200 MG
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Orbifloxacin is an orally administrable antibiotic that disrupts the replication and proliferation of bacterial DNA, inhibiting bacterial growth and exerting bactericidal activity. It has been shown to inhibit the growth of canine-derived *E. coli* and *Pseudomonas aeruginosa* isolates, and is used in research related to bacterial infections.
- Antibiotic mechanism: Disrupts bacterial DNA replication and proliferation, leading to bactericidal activity.
- Target: Quinolone.
- Inhibits the growth of *Piscirickettsia salmonis* LF-89 VR-1361 (0.015-4.0 μg/mL) with sustained effect over 7 days.
- Induces post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PA-SME) in clinical canine isolates.
- Exhibits concentration-dependent bactericidal activity against *Staphylococcus aureus* and time-dependent bactericidal activity against *Staphylococcus intermedius*.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000760693 6-BROMOHEXAN-1-AMINE 10G
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Sigma Aldrich Fine Chemicals Biosciences PTAA a polytriaryl amine s1G
PTAA poly(triaryl amine) semiconductor is an organic p-type semiconductor with hole mobilities of 10A3nbspup to 10A2nbspcm2nbspVA1nbspsA1 which results in a high carrier mobility. It is a stable glassy polymer and has good ionization potential for thick film diodes.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000691116 DIHYDREXIDINE HYDRO 25MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000759885 DISODIUM 3 3 -SULFON 1G
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Apexbio Technology LLC Sodium Phenylbutyrate 1716-12-7 200mg
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Sodium Phenylbutyrate (CAS 1716-12-7) is a small-molecule inhibitor targeting histone deacetylase (HDAC) an enzyme involved in regulating histone acetylation an epigenetic mechanism implicated in cancer progression and cardiac dysfunction In oral squamous cell carcinoma cell lines (CAL27 HSC3 SCC4) Sodium Phenylbutyrate demonstrated dose-dependent cell growth inhibition (IC50 4 091 3 712 and 3 015 mM respectively) and decreased cell viability in a time-dependent manner In a mouse Adriamycin-induced cardiac injury model treatment with Sodium Phenylbutyrate significantly attenuated cardiac enzyme elevations improved cardiac function and increased cardiac MnSOD protein expression and activity Sodium Phenylbutyrate serves as an important research tool for cancer biology and cardiotoxicity studies
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000758306 6-2 3 3-TRIMETHYL-3 250MG
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